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Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.

3-Phosphoinositide-dependent protein kinase-1 (PDK1) interacts stereoselectively with the d-enantiomer of PtdIns(3,4,5)P3 (KD 1.6 nM) and PtdIns(3,4)P2 (KD 5.2 nM), but binds with lower affinity to PtdIns3P or PtdIns(4,5)P2. The binding of PtdIns(3,4,5)P3 to PDK1 was greatly decreased by making spec...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Currie, R A, Walker, K S, Gray, A, Deak, M, Casamayor, A, Downes, C P, Cohen, P, Alessi, D R, Lucocq, J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1999
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220012/
https://ncbi.nlm.nih.gov/pubmed/9895304
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