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Design of a transferrin-proteinase inhibitor conjugate to probe for active cysteine proteinases in endosomes.

A new technique has been developed to identify active proteinases in endosomes that does not require prior isolation of organelles and extraction of the active enzymes. [125I]Iodotyrosylalanyldiazomethane was reversibly conjugated to transferrin to selectively deliver it to endosomes. The protein wa...

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Bibliographic Details
Main Authors: Xing, R, Mason, R W
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219918/
https://ncbi.nlm.nih.gov/pubmed/9841879
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