Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels.

Sialylation of N-glycans associated with recombinant human acetylcholinesterase (rHuAChE) has a central role in determining its circulatory clearance rate. Human embryonal kidney 293 (HEK-293) cells, which are widely used for the expression of recombinant proteins, seem to be limited in their abilit...

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Autores principales: Chitlaru, T, Kronman, C, Zeevi, M, Kam, M, Harel, A, Ordentlich, A, Velan, B, Shafferman, A
Formato: Artigo
Lenguaje:Inglês
Publicado: 1998
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219916/
https://ncbi.nlm.nih.gov/pubmed/9841877
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