Mutagenesis of Glu403 to Cys in rabbit neutral endopeptidase-24.11 (neprilysin) creates a disulphide-linked homodimer: analogy with endothelin-converting enzyme.

Neutral endopeptidase-24.11 (NEP; neprilysin; EC 3.4.24.11) and endothelin-converting enzyme (ECE) are related zinc metallopeptidases involved in the processing of biologically active peptides. Only ECE, however, exists as a disulphide-linked homodimer. The covalent linkage in rat ECE is between Cys...

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Main Authors: Hoang, M V, Sansom, C E, Turner, A J
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1218876/
https://ncbi.nlm.nih.gov/pubmed/9581575
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