Targeting of the HIV-1 long terminal repeat with chromomycin potentiates the inhibitory effects of a triplex-forming oligonucleotide on Sp1-DNA interactions and in vitro transcription.

We have studied the effects of chromomycin and of a triple-helix-forming oligonucleotide (TFO) that recognizes Sp1 binding sites on protein-DNA interactions and HIV-1 transcription. Molecular interactions between chromomycin, the Sp1 TFO and target DNA sequences were studied by gel retardation, trip...

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Detalhes bibliográficos
Main Authors: Bianchi, N, Rutigliano, C, Passadore, M, Tomassetti, M, Pippo, L, Mischiati, C, Feriotto, G, Gambari, R
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1218751/
https://ncbi.nlm.nih.gov/pubmed/9307046
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