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G-protein betagamma subunits antagonize protein kinase C-dependent phosphorylation and inhibition of phospholipase C-beta1.
Protein kinase C (PKC) isoforms phosphorylated phospholipase C-beta1 (PLC-beta1) in vitro as follows: PKCalpha >> PKCepsilon; not PKCzeta. PLC-beta3 was not phosphorylated by PKCalpha. G-protein betagamma subunits inhibited the PKCalpha phosphorylation of PLC-beta1 in a concentration-dependent...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
1997
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1218724/ https://ncbi.nlm.nih.gov/pubmed/9307019 |
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