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pH-dependent DNA cleavage in permeabilized human fibroblasts.

In several cell types, apoptosis is associated with intracellular acidification and activation of a pH-dependent endonuclease. We have examined the effect of acidic pH on the DNA of permeabilized human fibroblasts, and observed cleavage of DNA into high-molecular-mass fragments. This pH-dependent DN...

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Main Authors: Czene, S, Tibäck, M, Harms-Ringdahl, M
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1218324/
https://ncbi.nlm.nih.gov/pubmed/9163321
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