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Trypsin stimulates proteinase-activated receptor-2-dependent and -independent activation of mitogen-activated protein kinases.

We have examined protease-mediated activation of the mitogen-activated protein (MAP) kinase cascade in rat aortic smooth-muscle cells and bovine pulmonary arterial fibroblasts. Exposure of smooth-muscle cells to trypsin evoked rapid and transient activation of c-Raf-1, MAP kinase kinase 1 and 2 and...

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Dettagli Bibliografici
Autori principali: Belham, C M, Tate, R J, Scott, P H, Pemberton, A D, Miller, H R, Wadsworth, R M, Gould, G W, Plevin, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1218019/
https://ncbi.nlm.nih.gov/pubmed/9003384
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