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A Population-Genetic Test of Founder Effects and Implications for Ashkenazi Jewish Diseases

A founder effect can account for the presence of an allele at an unusually high frequency in an isolated population if the allele is selectively neutral and if all copies are identical by descent with a copy that either was carried by a founder individual or arose by mutation later. Here, a statisti...

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Bibliografiske detaljer
Hovedforfatter: Slatkin, Montgomery
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Human Genetics 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1216062/
https://ncbi.nlm.nih.gov/pubmed/15208782
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