Meta-Analysis of 13 Genome Scans Reveals Multiple Cleft Lip/Palate Genes with Novel Loci on 9q21 and 2q32-35

Isolated or nonsyndromic cleft lip with or without cleft palate (CL/P) is a common birth defect with a complex etiology. A 10-cM genome scan of 388 extended multiplex families with CL/P from seven diverse populations (2,551 genotyped individuals) revealed CL/P genes in six chromosomal regions, inclu...

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Main Authors: Marazita, Mary L., Murray, Jeffrey C., Lidral, Andrew C., Arcos-Burgos, Mauricio, Cooper, Margaret E., Goldstein, Toby, Maher, Brion S., Daack-Hirsch, Sandra, Schultz, Rebecca, Mansilla, M. Adela, Field, L. Leigh, Liu, You-e, Prescott, Natalie, Malcolm, Sue, Winter, Robin, Ray, Ajit, Moreno, Lina, Valencia, Consuelo, Neiswanger, Katherine, Wyszynski, Diego F., Bailey-Wilson, Joan E., Albacha-Hejazi, Hasan, Beaty, Terri H., McIntosh, Iain, Hetmanski, Jacqueline B., Tunçbilek, Gökhan, Edwards, Matthew, Harkin, Louise, Scott, Rodney, Roddick, Laurence G.
Format: Artigo
Language:Inglês
Published: The American Society of Human Genetics 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1216052/
https://ncbi.nlm.nih.gov/pubmed/15185170
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