MYC Abrogates p53-Mediated Cell Cycle Arrest in N-(Phosphonacetyl)-l-Aspartate-Treated Cells, Permitting CAD Gene Amplification

Genomic instability, including the ability to undergo gene amplification, is a hallmark of neoplastic cells. Similar to normal cells, “nonpermissive” REF52 cells do not develop resistance to N-(phosphonacetyl)-l-aspartate (PALA), an inhibitor of the synthesis of pyrimidine nucleotides, through ampli...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Chernova, Olga B., Chernov, Michail V., Ishizaka, Yukihito, Agarwal, Munna L., Stark, George R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1998
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC121521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9418900/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.1.536
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