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Identification of 9,17-Dioxo-1,2,3,4,10,19-Hexanorandrostan-5-oic Acid, 4-Hydroxy-2-Oxohexanoic Acid, and 2-Hydroxyhexa-2,4-Dienoic Acid and Related Enzymes Involved in Testosterone Degradation in Comamonas testosteroni TA441

Comamonas testosteroni TA441 utilizes testosterone via aromatization of the A ring followed by meta-cleavage of the ring. The product of the meta-cleavage reaction, 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-dien-4-oic acid, is degraded by a hydrolase, TesD. We directly isolated and ide...

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Sonraí Bibleagrafaíochta
Main Authors: Horinouchi, Masae, Hayashi, Toshiaki, Koshino, Hiroyuki, Kurita, Tomokazu, Kudo, Toshiaki
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2005
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1214608/
https://ncbi.nlm.nih.gov/pubmed/16151114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.71.9.5275-5281.2005
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