Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein

BACKGROUND: The amyloid precursor protein (APP) is transported via the secretory pathway to the cell surface, where it may be cleaved within its ectodomain by α-secretase, or internalized within clathrin-coated vesicles. An alternative proteolytic pathway occurs within the endocytic compartment, whe...

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Main Authors: Carey, Robyn M, Balcz, Brigitte A, Lopez-Coviella, Ignacio, Slack, Barbara E
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2005
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1208872/
https://ncbi.nlm.nih.gov/pubmed/16095541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-6-30
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