Destabilization of Simple Repetitive DNA Sequences by Transcription in Yeast

Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels...

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Autores principales: Wierdl, M., Greene, C. N., Datta, A., Jinks-Robertson, S., Petes, T. D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
Materias:
Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1207331/
https://ncbi.nlm.nih.gov/pubmed/8725221
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