Vph6 Mutants of Saccharomyces Cerevisiae Require Calcineurin for Growth and Are Defective in Vacuolar H(+)-Atpase Assembly

We have characterized a Saccharomyces cerevisiae mutant strain that is hypersensitive to cyclosporin A (CsA) and FK506, immunosuppressants that inhibit calcineurin, a serine-threonine-specific phosphatase (PP2B). A single nuclear mutation, designated cev1 for calcineurin essential for viability, is...

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Bibliographic Details
Main Authors: Hemenway, C. S., Dolinski, K., Cardenas, M. E., Hiller, M. A., Jones, E. W., Heitman, J.
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1206848/
https://ncbi.nlm.nih.gov/pubmed/8582630
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