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Structural Requirements For In Vivo Detection of Cell Death with (99m)Tc-Annexin V

(99m)Tc-annexin V is used to image cell death in vivo via high-affinity binding to exposed phosphatidylserine. We investigated how changes in membrane binding affinity, molecular charge, and method of labeling affected its biodistribution in normal mice and its uptake in apoptotic tissues. METHODS:...

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Detalhes bibliográficos
Main Authors: Tait, Jonathan F, Smith, Christina, Blankenberg, Francis G
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201384/
https://ncbi.nlm.nih.gov/pubmed/15872355
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