Involvement of Ganglioside GM3 in G(2)/M Cell Cycle Arrest of Human Monocytic Cells Induced by Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin

Actinobacillus actinomycetemcomitans produces a toxin called cytolethal distending toxin (CDT), which causes host cell DNA damage leading to the induction of DNA damage checkpoint pathways. CDT consists of three subunits, CdtA, CdtB, and CdtC. CdtB is the active subunit of CDT and exerts its effect...

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Detalhes bibliográficos
Main Authors: Mise, Koji, Akifusa, Sumio, Watarai, Shinobu, Ansai, Toshihiro, Nishihara, Tatsuji, Takehara, Tadamichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201191/
https://ncbi.nlm.nih.gov/pubmed/16040998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.8.4846-4852.2005
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