Involvement of Ganglioside GM3 in G(2)/M Cell Cycle Arrest of Human Monocytic Cells Induced by Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin

Actinobacillus actinomycetemcomitans produces a toxin called cytolethal distending toxin (CDT), which causes host cell DNA damage leading to the induction of DNA damage checkpoint pathways. CDT consists of three subunits, CdtA, CdtB, and CdtC. CdtB is the active subunit of CDT and exerts its effect...

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Bibliographische Detailangaben
Hauptverfasser: Mise, Koji, Akifusa, Sumio, Watarai, Shinobu, Ansai, Toshihiro, Nishihara, Tatsuji, Takehara, Tadamichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201191/
https://ncbi.nlm.nih.gov/pubmed/16040998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.8.4846-4852.2005
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