Augmentation of the Lipopolysaccharide-Neutralizing Activities of Human Cathelicidin CAP18/LL-37-Derived Antimicrobial Peptides by Replacement with Hydrophobic and Cationic Amino Acid Residues

Mammalian myeloid and epithelial cells express various peptide antibiotics (such as defensins and cathelicidins) that contribute to the innate host defense against invading microorganisms. Among these peptides, human cathelicidin CAP18/LL-37 (L(1) to S(37)) possesses not only potent antibacterial ac...

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Detalhes bibliográficos
Main Authors: Nagaoka, Isao, Hirota, Satoko, Niyonsaba, François, Hirata, Michimasa, Adachi, Yoshiyuki, Tamura, Hiroshi, Tanaka, Shigenori, Heumann, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Microbial Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC120071/
https://ncbi.nlm.nih.gov/pubmed/12204946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CDLI.9.5.972-982.2002
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