Interleukin-18 Induces Acute Biphasic Reduction in the Levels of Circulating Leukocytes in Mice

We investigated the acute hematological changes caused by interleukin-18 (IL-18) in mice. Intraperitoneal administration of IL-18 (2 μg/mouse) resulted in biphasic decreases in the number of leukocytes in the blood. The first phase of decrease occurred within 2 h of IL-18 administration and was foll...

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Bibliografiske detaljer
Main Authors: Hosohara, Katsushi, Ueda, Haruyasu, Kashiwamura, Shin-Ichiro, Yano, Takako, Ogura, Takeharu, Marukawa, Seishiro, Okamura, Haruki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Antibodies and Mediators of Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC120031/
https://ncbi.nlm.nih.gov/pubmed/12093672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CDLI.9.4.777-783.2002
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