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Discovering statistically significant pathways in expression profiling studies

Accurate and rapid identification of perturbed pathways through the analysis of genome-wide expression profiles facilitates the generation of biological hypotheses. We propose a statistical framework for determining whether a specified group of genes for a pathway has a coordinated association with...

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Autori principali: Tian, Lu, Greenberg, Steven A., Kong, Sek Won, Altschuler, Josiah, Kohane, Isaac S., Park, Peter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1200092/
https://ncbi.nlm.nih.gov/pubmed/16174746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506577102
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