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Reduction of nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair
Assembly of new chromatin during S phase requires the histone chaperone complexes CAF-1 (Cac2p, Msi1p and Rlf2p) and RCAF (Asf1p plus acetylated histones H3 and H4). Cells lacking CAF-1 and RCAF are hypersensitive to DNA-damaging agents, such as methyl methanesulfonate and camptothecin, suggesting a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1197131/ https://ncbi.nlm.nih.gov/pubmed/16141196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki806 |
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