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Regulation of α-Synuclein Expression by Poly (ADP Ribose) Polymerase-1 (PARP-1) Binding to the NACP-Rep1 Polymorphic Site Upstream of the SNCA Gene

Alleles at NACP-Rep1, the polymorphic microsatellite repeat located ∼10 kb upstream of the α-synuclein gene (SNCA), are associated, in some reports, with differing risks of sporadic Parkinson disease (PD). We showed previously that NACP-Rep1 acts as a negative modulator of SNCA transcription, with a...

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Bibliografski detalji
Glavni autori: Chiba-Falek, Ornit, Kowalak, Jeffrey A., Smulson, Mark E., Nussbaum, Robert L.
Format: Artigo
Jezik:Inglês
Izdano: The American Society of Human Genetics 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196399/
https://ncbi.nlm.nih.gov/pubmed/15672325
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