Pharmacokinetics of Nelfinavir and Efavirenz in Antiretroviral-Naïve, Human Immunodeficiency Virus-Infected Subjects when Administered Alone or in Combination with Nucleoside Analog Reverse Transcriptase Inhibitors

Pharmacokinetic studies were conducted with human immunodeficiency virus-infected patients receiving efavirenz, nelfinavir, or both agents at weeks 4 and 32. Reductions of 25% and 45% were observed in the mean nelfinavir area under the concentration-time curve and minimum concentration of the drug i...

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Bibliographic Details
Main Authors: Smith, Patrick F., Robbins, Gregory K., Shafer, Robert W., Wu, Hulin, Yu, Song, Hirsch, Martin S., Merigan, Thomas C., Park, Jeong-Gun, Forrest, Alan, Fischl, Margaret A., Morse, Gene D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Clinical Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196281/
https://ncbi.nlm.nih.gov/pubmed/16048984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3558-3561.2005
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