Integron-Encoded GES-Type Extended-Spectrum β-Lactamase with Increased Activity toward Aztreonam in Pseudomonas aeruginosa

A Pseudomonas aeruginosa strain expresses an extended-spectrum β-lactamase, GES-9, which differs from GES-1 by a Gly243Ser substitution, is inhibited by clavulanic acid and imipenem, and hydrolyzes aztreonam. The bla(GES-9) gene was located inside a class 1 integron structure containing two copies o...

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Bibliographische Detailangaben
Hauptverfasser: Poirel, Laurent, Brinas, Laura, Fortineau, Nicolas, Nordmann, Patrice
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196234/
https://ncbi.nlm.nih.gov/pubmed/16048994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3593-3597.2005
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