Association between the Pharmacokinetics and In Vivo Therapeutic Efficacy of Sulfadoxine-Pyrimethamine in Malawian Children

Sulfadoxine-pyrimethamine (SP) has been widely used in recent years to treat acute uncomplicated Plasmodium falciparum malaria. Risk factors for SP therapeutic failure include young age, subtherapeutic SP concentrations, and resistance-conferring genetic mutations in parasite target enzymes. A subst...

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Главные авторы: Dzinjalamala, Fraction K., Macheso, Allan, Kublin, James G., Taylor, Terrie E., Barnes, Karen I., Molyneux, Malcolm E., Plowe, Christopher V., Smith, Peter J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2005
Предметы:
Clinical Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195435/
https://ncbi.nlm.nih.gov/pubmed/16127028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3601-3606.2005
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