Activities of Rifamycin Derivatives against Wild-Type and rpoB Mutants of Chlamydia trachomatis

Rifalazil, a semisynthetic rifamycin, was shown previously to have exceptional potency against Chlamydia trachomatis (MIC of 0.00025 μg/ml). We therefore tested 250 additional rifamycin derivatives and identified 12 with activities that are eightfold more potent than that of rifalazil. These compoun...

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Detalhes bibliográficos
Main Authors: Xia, Minsheng, Suchland, Robert J., Carswell, Joli A., Van Duzer, John, Buxton, Debra K., Brown, Kara, Rothstein, David M., Stamm, Walter E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195391/
https://ncbi.nlm.nih.gov/pubmed/16127086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3974-3976.2005
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