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Molecular Origin of Polyglutamine Aggregation in Neurodegenerative Diseases
Expansion of polyglutamine (polyQ) tracts in proteins results in protein aggregation and is associated with cell death in at least nine neurodegenerative diseases. Disease age of onset is correlated with the polyQ insert length above a critical value of 35–40 glutamines. The aggregation kinetics of...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2005
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1193989/ https://ncbi.nlm.nih.gov/pubmed/16158094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0010030 |
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