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Calcium block of guinea-pig heart sodium channels with and without modification by the piperazinylindole DPI 201-106.
1. External Ca2+ block of Na+ channels was studied by a gigaohm-seal patch clamp technique in single cardiac ventricular cells from guinea-pig. Single-channel currents were recorded from cell-attached patches. 2. Increasing external Ca2+ concentrations in the patch pipette from 0.1 to 20 mM reduced...
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| Hovedforfatter: | |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1988
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1191679/ https://ncbi.nlm.nih.gov/pubmed/2457094 |
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