The Transmembrane Adapter Protein SIT Regulates Thymic Development and Peripheral T-Cell Functions

SIT is a transmembrane adapter protein that modulates signals emanating from the T-cell receptor (TCR). Here, we have used gene-targeted mice to assess the role of SIT for T-cell development and peripheral T-cell functions. SIT(−/−) double-positive thymocytes show an upregulation of the activation m...

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Auteurs principaux: Simeoni, Luca, Posevitz, Vilmos, Kölsch, Uwe, Meinert, Ines, Bruyns, Eddy, Pfeffer, Klaus, Reinhold, Dirk, Schraven, Burkhart
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190311/
https://ncbi.nlm.nih.gov/pubmed/16107703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7557-7568.2005
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