Manganese Superoxide Dismutase Induces p53-Dependent Senescence in Colorectal Cancer Cells

The mitochondrial enzyme manganese superoxide dismutase (MnSOD) is known to suppress cell growth in different tumor cell lines. However, the molecular mechanism of this growth-retarding effect is not fully understood. Here we show that overexpression of MnSOD slows down growth of HCT116 human colore...

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Bibliographic Details
Main Authors: Behrend, Lars, Mohr, Andrea, Dick, Tatjana, Zwacka, Ralf M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190300/
https://ncbi.nlm.nih.gov/pubmed/16107721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7758-7769.2005
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