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Reversal and inhibition of cholera toxin-induced secretion in isolated rabbit ileum.

1. Cholera toxin (1 microgram/ml) abolished net fluid absorption by everted sacs of rabbit ileum, leading to net fluid secretion. This action occurred via the toxin-catalysed ADP ribosylation of the stimulatory GTP-binding protein Gs which is linked to adenylate cyclase. Nicotinamide (10 mM), a reac...

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Detalhes bibliográficos
Main Authors: Falk, G, Freeman, M, Marshall, A T, Prenton, E, Shiells, R A, Slack, I
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190091/
https://ncbi.nlm.nih.gov/pubmed/2140861
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