Epithelial membrane protein-1 is a biomarker of gefitinib resistance

We describe a molecular resistance biomarker to gefitinib, epithelial membrane protein-1 (EMP-1). Gefitinib is a small-molecule inhibitor that competes for the ATP-binding site on EGF receptor (EGFR) and has been approved for patients with advanced lung cancers. Treatment with gefitinib has resulted...

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Hlavní autoři: Jain, Anjali, Tindell, Charles A., Laux, Isett, Hunter, Jacob B., Curran, John, Galkin, Anna, Afar, Daniel E., Aronson, Nina, Shak, Steven, Natale, Ronald B., Agus, David B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187965/
https://ncbi.nlm.nih.gov/pubmed/16087880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502113102
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