Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin

The tuberculosis vaccine Mycobacterium bovis bacille Calmette-Guérin (BCG) was equipped with the membrane-perforating listeriolysin (Hly) of Listeria monocytogenes, which was shown to improve protection against Mycobacterium tuberculosis. Following aerosol challenge, the Hly-secreting recombinant BC...

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Main Authors: Grode, Leander, Seiler, Peter, Baumann, Sven, Hess, Jürgen, Brinkmann, Volker, Eddine, Ali Nasser, Mann, Peggy, Goosmann, Christian, Bandermann, Silke, Smith, Debbie, Bancroft, Gregory J., Reyrat, Jean-Marc, van Soolingen, Dick, Raupach, Bärbel, Kaufmann, Stefan H.E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2005
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187936/
https://ncbi.nlm.nih.gov/pubmed/16110326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24617
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