Frequent loss of SMAD4/DPC4 protein in colorectal cancers

Background and aims: Loss of DNA sequences from chromosome 18q21 is a major genetic change in colorectal tumorigenesis. Multiple genes have been identified in this area. One of these, DPC4 (deleted in pancreatic cancer 4, also known as SMAD4), is mutated in a minor subset of colorectal carcinomas as...

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Main Authors: Salovaara, R, Roth, S, Loukola, A, Launonen, V, Sistonen, P, Avizienyte, E, Kristo, P, Järvinen, H, Souchelnytskyi, S, Sarlomo-Rikala, M, Aaltonen, L A
Format: Artigo
Jezik:Inglês
Izdano: British Medical Journal Publishing Group 2002
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Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187276/
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