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Paroxysmal nocturnal haemoglobinuria: Nature's gene therapy?

The development of paroxysmal nocturnal haemoglobinuria (PNH) requires two coincident factors: somatic mutation of the PIG-A gene in one or more haemopoietic stem cells and an abnormal, hypoplastic bone marrow environment. When both of these conditions are met, the fledgling PNH clone may flourish....

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Bibliografiske detaljer
Main Authors: Johnson, R J, Hillmen, P
Format: Artigo
Sprog:Inglês
Udgivet: British Medical Journal Publishing Group 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187166/
https://ncbi.nlm.nih.gov/pubmed/12032224
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