Limitations of clonality analysis of B cell proliferations using CDR3 polymerase chain reaction

Background/Aims—Detection of clonal immunoglobulin heavy chain (IgH) rearrangements by the polymerase chain reaction (PCR) is an attractive alternative to Southern blotting in lymphoma diagnostics. However, the advantages and limitations of PCR in clonality analysis are still not fully appreciated....

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Main Authors: Hoeve, M A, Krol, A D G, Philippo, K, Derksen, P W B, Veenendaal, R A, Schuuring, E, Kluin, Ph M, Krieken, J H J M van
Formato: Artigo
Idioma:Inglês
Publicado em: British Medical Journal Publishing Group 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1186969/
https://ncbi.nlm.nih.gov/pubmed/11040942
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