The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.

1. In isolated pancreatic islets, pyruvate causes a shift to the left of the sigmoidal curve relating the rate of insulin release to the ambient glucose concentration. The magnitude of this effect is related to the concentration of pyruvate (5--90 mM) and, at a 30 mM concentration, is equivalent to...

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Main Authors: Sener, A, Kawazu, S, Hutton, J C, Boschero, A C, Devis, G, Somers, G, Herchuelz, A, Malaisse, W J
Format: Artigo
Jezik:Inglês
Izdano: 1978
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1186223/
https://ncbi.nlm.nih.gov/pubmed/365174
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