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Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

1. In neutral aqueous solution N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) yields salts of nitrocyanamide as u.v.-absorbing products. With cysteine, as found independently by Schulz & McCalla (1969), the principal product is 2-nitràminothiazoline-4-carboxylic acid. Both these reactions liberate...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Lawley, P. D., Thatcher, Carolyn J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 1970
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1185415/
https://ncbi.nlm.nih.gov/pubmed/5435496
תגים: הוספת תג
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