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Microbiological degradation of bile acids. Ring a cleavage and 7α,12α-dehydroxylation of cholic acid by Arthrobacter simplex

The metabolism of cholic acid by Arthrobacter simplex was investigated. This organism effected both ring a cleavage and elimination of the hydroxyl groups at C-7 and C-12 and gave a new metabolite, (4R)-4-[4α-(2-carboxyethyl)-3aα-hexahydro-7aβ-methyl-5-oxoindan-1β-yl]valeric acid, which was isolated...

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Autors principals: Hayakawa, Shohei, Kanematsu, Yoshiko, Fujiwara, Takashi
Format: Artigo
Idioma:Inglês
Publicat: 1969
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1185096/
https://ncbi.nlm.nih.gov/pubmed/5378382
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