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Alteration of P-type calcium channel gating by the spider toxin omega-Aga-IVA.

We studied the mechanism of inhibition of P-type calcium channels in rat cerebellar Purkinje neurons by the peptide toxin omega-Aga-IVA. Saturating concentrations of omega-Aga-IVA (> 50 nM) inhibited inward current carried by 2-5 mM Ba almost completely. However, outward current at depolarization...

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Detalhes bibliográficos
Main Authors: McDonough, S I, Mintz, I M, Bean, B P
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184405/
https://ncbi.nlm.nih.gov/pubmed/9129813
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