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Identification of a pore lining segment in gap junction hemichannels.

The ability of certain connexins to form open hemichannels has been exploited to study the pore structure of gap junction (hemi)channels. Cysteine scanning mutagenesis was applied to cx46 and to a chimeric connexin, cx32E(1)43, which both form patent hemichannels when expressed in Xenopus oocytes. T...

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Main Authors: Zhou, X W, Pfahnl, A, Werner, R, Hudder, A, Llanes, A, Luebke, A, Dahl, G
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184391/
https://ncbi.nlm.nih.gov/pubmed/9129799
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