Organ-specific roles for transcription factor NF-κB in reovirus-induced apoptosis and disease

Reovirus induces apoptosis in cultured cells and in vivo. In cell culture models, apoptosis is contingent upon a mechanism involving reovirus-induced activation of transcription factor NF-κB complexes containing p50 and p65/RelA subunits. To explore the in vivo role of NF-κB in this process, we test...

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Detalhes bibliográficos
Main Authors: O’Donnell, Sean M., Hansberger, Mark W., Connolly, Jodi L., Chappell, James D., Watson, Melissa J., Pierce, Janene M., Wetzel, J. Denise, Han, Wei, Barton, Erik S., Forrest, J. Craig, Valyi-Nagy, Tibor, Yull, Fiona E., Blackwell, Timothy S., Rottman, Jeffrey N., Sherry, Barbara, Dermody, Terence S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184036/
https://ncbi.nlm.nih.gov/pubmed/16100570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI22428
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