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Multiple interactions of the ‘transducer’ govern its function in calpain activation by Ca(2+)
Typical calpains in mammals become activated on binding of 8–12 Ca(2+) ions per enzyme molecule, giving an example of integrated, manifold regulation by calcium. Besides two identified Ca(2+) sites in catalytic domain II and several EF-hand motifs in domains IV and VI, an acidic loop in the centrall...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1183452/ https://ncbi.nlm.nih.gov/pubmed/15569003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041935 |
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