TAF4 inactivation in embryonic fibroblasts activates TGFβ signalling and autocrine growth

We have inactivated transcription factor TFIID subunit TBP-associated factor 4 (TAF4) in mouse embryonic fibroblasts. Mutant taf4(−/−) cells are viable and contain intact TFIID comprising the related TAF4b showing that TAF4 is not an essential protein. TAF4 inactivation deregulates more than 1000 ge...

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Autors principals: Mengus, Gabrielle, Fadloun, Anas, Kobi, Dominique, Thibault, Christelle, Perletti, Lucia, Michel, Isabelle, Davidson, Irwin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2005
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182243/
https://ncbi.nlm.nih.gov/pubmed/16015375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600748
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