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Transmission-Ratio Distortion and Allele Sharing in Affected Sib Pairs: A New Linkage Statistic with Reduced Bias, with Application to Chromosome 6q25.3

We studied the effect of transmission-ratio distortion (TRD) on tests of linkage based on allele sharing in affected sib pairs. We developed and implemented a discrete-trait allele-sharing test statistic, S(ad), analogous to the S(pairs) test statistic of Whittemore and Halpern, that evaluates an ex...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Lemire, Mathieu, Roslin, Nicole M., Laprise, Catherine, Hudson, Thomas J., Morgan, Kenneth
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society of Human Genetics 2004
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182045/
https://ncbi.nlm.nih.gov/pubmed/15322985
תגים: הוספת תג
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