Dissection of Genomewide-Scan Data in Extended Families Reveals a Major Locus and Oligogenic Susceptibility for Age-Related Macular Degeneration

To examine the genetic basis of age-related macular degeneration (ARMD), a degenerative disease of the retinal pigment epithelium and neurosensory retina, we conducted a genomewide scan in 34 extended families (297 individuals, 349 sib pairs) ascertained through index cases with neovascular disease...

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Main Authors: Iyengar, Sudha K., Song, Danhong, Klein, Barbara E. K., Klein, Ronald, Schick, James H., Humphrey, Jennifer, Millard, Christopher, Liptak, Rachel, Russo, Karlie, Jun, Gyungah, Lee, Kristine E., Fijal, Bonnie, Elston, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society of Human Genetics 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1181910/
https://ncbi.nlm.nih.gov/pubmed/14691731
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