Suppression of RNA Interference by Adenovirus Virus-Associated RNA

We show that human adenovirus inhibits RNA interference (RNAi) at late times of infection by suppressing the activity of two key enzyme systems involved, Dicer and RNA-induced silencing complex (RISC). To define the mechanisms by which adenovirus blocks RNAi, we used a panel of mutant adenoviruses d...

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Detalhes bibliográficos
Main Authors: Andersson, M. Gunnar, Haasnoot, P. C. Joost, Xu, Ning, Berenjian, Saideh, Berkhout, Ben, Akusjärvi, Göran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1181602/
https://ncbi.nlm.nih.gov/pubmed/16014917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.15.9556-9565.2005
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