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Shutoff of RNA Polymerase II Transcription by Poliovirus Involves 3C Protease-Mediated Cleavage of the TATA-Binding Protein at an Alternative Site: Incomplete Shutoff of Transcription Interferes with Efficient Viral Replication

The TATA-binding protein (TBP) plays a crucial role in cellular transcription catalyzed by all three DNA-dependent RNA polymerases. Previous studies have shown that TBP is targeted by the poliovirus (PV)-encoded protease 3C(pro) to bring about shutoff of cellular RNA polymerase II-mediated transcrip...

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Autors principals: Kundu, Pallob, Raychaudhuri, Santanu, Tsai, Weimin, Dasgupta, Asim
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1181600/
https://ncbi.nlm.nih.gov/pubmed/16014932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.15.9702-9713.2005
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