Calcium channel block by (-)devapamil is affected by the sequence environment and composition of the phenylalkylamine receptor site.

The pore-forming alpha 1 subunit of L-type calcium (Ca2+) channels is the molecular target of Ca2+ channel blockers such as phenylalkylamines (PAAs). Association and dissociation rates of (-)devapamil were compared for a highly PAA-sensitive L-type Ca2+ channel chimera (Lh) and various class A Ca2+...

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Detalhes bibliográficos
Main Authors: Degtiar, V E, Aczél, S, Döring, F, Timin, E N, Berjukow, S, Kimball, D, Mitterdorfer, J, Hering, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180917/
https://ncbi.nlm.nih.gov/pubmed/9199780
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