Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients

Proinsulin is a key autoantigen in type 1 diabetes. Evidence in the mouse has underscored the importance of the insulin B chain region in autoimmunity to pancreatic beta cells. In man, a majority of proteasome cleavage sites are predicted by proteasome cleavage algorithms within this region. To stud...

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Main Authors: Toma, Andréa, Haddouk, Samy, Briand, Jean-Paul, Camoin, Luc, Gahery, Hanne, Connan, Francine, Dubois-Laforgue, Danielle, Caillat-Zucman, Sophie, Guillet, Jean-Gérard, Carel, Jean-Claude, Muller, Sylviane, Choppin, Jeannine, Boitard, Christian
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180789/
https://ncbi.nlm.nih.gov/pubmed/16030147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504230102
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